Frequency of Statin-Induced Myopathy in Patients with Dyslipidemia Presenting in a Tertiary Care Hospital of Lahore

Abstract

Background: Frequency of dyslipidemia is on continuous rise in the developing countries including Pakistan. Many studies have shown that a raised LDL-cholesterol level, non-HDL cholesterol levels and decreased HDL-cholesterol levels are related with anraised risk of cardiovascular diseases and also certain muscle related symptoms. Aim: To find the frequency of statin-induced myopathy in dyslipidemic patients presenting in a tertiary care hospital. Methods It was a cross sectional study conducted among dyslipidemic patients presented at department of medicine and endocrinology, Unit-I Fatima Memorial hospital, Lahore. Non-probability consecutive sampling technique was used to select 230 dyslipidemic patients who met the inclusion criteria. Information was recorded on predesigned questionnaire regarding statin induced myopathy and socio-demographic variables. Results: In this study, the mean age statin induced myopathy respondents was 49.9±8.6 years while it was 49.9±9.4 years among not having statin induced myopathy.Statin induced myopathy was seen in 55 (23.9%) respondents while in 175 (76.1%) there was no statin induced myopathy. Gender among peripheral neuropathy showed that males were 42 and females were 13 in number; and among non-statin induced myopathy group there were 121 males and 54 females. Most of the middle income respondents were suffering from statin induced myopathy as compared to other income groups. Conclusion: This study reports an increased prevalence of statin induced myopathy among dyslipidemic patients. Male respondents were more in number than females but both had shown insignificant relationship with statin induced myopathy. The age>45 years of the respondents showed significant statistical difference with gender. Keywords: Statin Induced Myopathy, Dyslipidemia, Lahore