Aloe Vera Gel Accelerates Wound Healing in Oral Mucosa by Promoting Epithelialization and Cell Proliferation (Fibroblasts)

Abstract

Aim: To evaluate the accelerating effects of Aloe vera gel on the healing process of tongue wounds. Study design: Experimental animal study. Place and duration of study: Department of Anatomy, Postgraduate Medical Institute (PGMI), Lahore Pakistan from 29th April 2021 to 29th October 2021. Methodology: Forty two albino rats were divided into one control (group A) and two experimental groups (groups B & C) with 14 rats in each group. Each group was divided into two sub groups with 7 rats each. Surgical excisional wounds were inflicted on anterior 2/3rd of dorsal surface of the tongue of each rat on day 1 of the study. The control group animals were given distilled water while animals in the experimental groups were given two different doses of Aloe vera gel daily (300 mg/kg and 500 mg/kg). Results Histological evaluation of the wounds revealed that epithelialization and fibroblast cell proliferation were promoted in Aloe vera groups as compared with the control groups. Healing time was significantly decreased in group B and C animals as compared with group A. Aloe vera gel accelerated healing in experimental groups. Conclusion: Aloe vera gel accelerates healing in tongue mucosa wounds in Wistar rats and it plays its role by bringing enhanced epithelialzation and fibrosis. Keywords: Haematoxylin & Eosin (H&E), Immune Histochemical (IHC), Effect