MICROBIOTA TRANSPLANTATION AND ITS ROLE IN AUTOIMUNNE DISEASES: LITERATURE REVIEW

Abstract

Introduction: Autoimmune diseases affect around 10% of the world population. Most of these are complex diseases caused by the interaction between genetic, epigenetic and environmental factors. Furthermore, autoimmune diseases have become the third largest chronic disease, after cardiovascular diseases and cancer. The human microbiome may play an important role in autoimmunity, as loss of immunological tolerance may be caused by changes in microbial composition. Microorganisms can provoke an immune response against the host if tolerance mechanisms fail for several reasons. Objective: To carry out a literature review evaluating the role of microbiota transplantation in patients with autoimmune diseases. Method: This is a bibliographic review, with a search for articles carried out through the Virtual Health Library (VHL), LILACS, PubMed and Scopus for all relevant articles that included in their theme the involvement of microbiota transplantation and its role in autoimmune diseases. Final considerations: Fecal microbiota transplantation (FMT) has a very important role for patients with autoimmune diseases (AD), especially individuals with type 1 diabetes mellitus, systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis, in which FMT has demonstrated promising results. for the treatment of these individuals. However, as the literature is still quite limited in relation to the type of donor and ideal dosage, in addition to the route of administration and treatment interval for each type of autoimmune disease, it is important to carry out targeted studies with the aim of evaluating the effects. benefits of FMT targeted to each AD, in addition to the possible adverse events and the particular characteristics of this procedure in the treatment of ADs associated with changes in intestinal flora.