ASSOCIATION OF ACE GENE I/D POLYMORPHISM WITH HYPERTENSION AND PHYSICAL ACTIVITY LEVEL IN ADOLESCENTS: A SYSTEMATIC REVIEW

Abstract

Hypertension (AH) is a worldwide public health problem that involves several risk factors such as genetic inheritance and a sedentary lifestyle, leading to several other complications. Although more adults are increasing, the prevalence has increased among adolescents. In this sense, the study aims to make a systematic review of the ACE I/D polymorphism and its relationship with the prevalence of hypertension and adolescents' physical activity level. A search was performed in the literature of PubMed and Scielo databases. The investigation was limited to articles written in the english language in the last ten years. Articles published between 2012 and 2022 were included. Among the 17,126 articles identified in the systematic review of the literature, when applying the exclusion criteria, 12 were selected for complete reading, finishing with seven articles chosen for the review. Although there are few studies with this theme, we observed that studies have advanced that demonstrate the DD genotype of ACE I/D polymorphism as the most significant predictor of AH and still seeking a greater consensus on the influence of physical activity in this process.