Author:
Ribeiro Rachel Melo,De Carvalho Mateus Balbino Barbosa,De Brito Junior Emanoel Ribeiro,De Lima Beatriz da Silva Ferreira,Andrade Lara Possapp,E Souza Gabriel Antonio Bezerra Costa,Moura Jhônata Costa,Penha Ellen Caroline da Silva
Abstract
Objective: Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae), is a medicinal plant traditionally used for the treatment of pain, skin inflammations, fractures, and cardiac diseases. This study aimed to review the main phytochemical constituents from D. ambrosoides leaves, and the structure-activity relation of different compounds. Methodology: literature review, carried out between December 2022 and April 2023, through a bibliographic survey, in accordance with the recommended guidelines of PRISMA. The following descriptors were used “Dysphania ambrosioides”, “Chenopodium ambrosioides”, “leaves”, “traditional uses”, and “phytochemical constituents”, combining them with Boolean operators “AND” e “OR”, using electronic databases PubMed, and Google Scholar, published in the last 20 years and that addressed the theme. Results: D. ambrosioides is a promising ethnomedicinal plant and its leaves are a source of bioactive compounds such as α-terpinene, α-terpinenyl-acetate, beta-cymene, p-cymene, piperitone, carvyl acetate, piperitol acetate, trans-ascaridol, carvacrol, thymol, and limonene. In addition, chrysin, patulin, piperoylpiperidine, and scopoletin are present in this species. For these, the literature reports different mechanisms of action: PPAR –y agonist, Inhibitor of aromatase, Activation of the L-arginine/NO/cGMP/KATP pathway, an inhibitor of fatty acid synthase, Increase in glutathione peroxidase, and superoxide dismutase. Final considerations: more extensive number of preclinical pharmacological studies are performed to elucidate the molecular mechanisms of the components of the Phyto complex (bioactive constituents) isolated from D. ambrosioides leaves so that there is greater progress in the scientific validation for the use of the leaves as a source of therapeutic agents.
Publisher
South Florida Publishing LLC
Reference58 articles.
1. ABDEL-WAHHAB MA, SAID A, HUEFNER A. NMR and Radical Scavenging Activities of Patuletin from Urtica urens. Against Aflatoxin B1. Institute of Phar 2005; 43: 515-525.
2. ADEJUMO OE, OWA-AGBANAH IS, KOLAPO AL, AYOOLA MD. Phytochemical and antisickling activities of Entandrophragma utile, Chenopodium ambrosioides and Petiveria alliacea. J Med Plants Res 2011; 5: 1531-5.
3. AHMED AA. Highly Oxygenated Monoterpenes from Chenopodium ambrosioides. J Nat Prod 2000; 63: 989-91.
4. ALBUQUERQUE UP, MEDEIROS PM, ALMEIDA ALS, MONTEIRO JM, LINS-NETO EMF, MELO JG, SANTOS JP. Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach, J Ethnopharmacology 2007; 114: 325-54.
5. ALBUQUERQUE UP. The Use of Medicinal Plants by the Cultural Descendants of African People in Brazil. Acta Farm Bonaerense 2001; 20: 139-44.