Development and Productization of an Additively Manufactured Spinal Fixation Device that Enables Bone Matrix Orientation Guidance

Author:

TAKAHASHI Hiroyuki1,WATANABE Ryota1,HOFFMANN Ilona1,YOKOTA Katsuhiko1,NAKASHIMA Yoshio1,ITO Manabu2,NAKANO Takayoshi3

Affiliation:

1. Reserch Department, Teijin Nakashima Medical Co., Ltd.

2. National Hospital Organization, Hokkaido Medical Center

3. Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University

Publisher

Sumart Processing Society for Minerals, Environment and Energy

Reference13 articles.

1. 1) World Population Prospects 2022: Summary of Results, 3 (2022).

2. 2) T. Ishimoto, Y. Kobayashi, M. Takahata, M. Ito, A. Matsugaki, H. Takahashi, R. Watanabe, T. Inoue, T. Matsuzaka, R. Ozasa, T. Hanawa, K. Yokota, Y. Nakashima and T. Nakano: “Outstanding in vivo mechanical integrity of additively manufactured spinal cages with a novel “honeycomb tree structure” design via guiding bone matrix orientation”, The Spine Journal, 22 (2022), 1742-1757.

3. 3) A. Matsugaki, M. Ito, MD, Y. Kobayashi, T. Matsuzaka, R. Ozasa, T. Ishimoto, H. Takahashi, R. Watanabe, T. Inoue, K. Yokota, Y. Nakashima, T. Kaito, S. Okada, T. Hanawa, Y. Matsuyama, M. Matsumoto, H. Taneichi and T. Nakano: “Innovative design of bone quality-targeted intervertebral spacer: accelerated functional fusion guiding oriented collagen and apatite microstructure without autologous bone graft”, The Spine Journal: The Spine Journal, 23 (2023), 609-620.

4. 4) T. Nakano, K. Kaibara, Y. Tabata, N. Nagata, S. Enomoto, E. Marukawa and Y. Umakoshi: “Unique alignment and texture of biological apatite crystallites in typical calcified tissues analyzed by microbeam X-ray diffractometer system”, Bone, 31(2002), 479-487.

5. 5) T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto and Y. Tabata: “Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using recombinant bone morphogenetic protein-2”, J. Bone Miner. Res., 28(2013), 1170-1179.

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