Affiliation:
1. Saratov State Medical University of V.I. Razumovsky
2. Astrakhan State Medical University
Abstract
The aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study design: A retrospective case-control study was conducted on all infants with NEC who were born between 201 0 and 2020. Medical histories of all infants diagnosed with NEC ≥ Bella IIA stage and corresponding controls without NEC were examined. Maternal and newborn char-acteristics were compared using the Cochran-Mantel-Haenszel method, and logistic regression models were constructed to account for bias.Results. Clinical data were analyzed for 97 matched pairs. The adjusted odds ratio (OR) for pre-natal ampicillin exposure was significantly higher for infants who developed NEC (OR 2.3, 95% CI 1.1,4.8, P = 0.003) than for children in the control group. Infants who developed NEC were more likely to have a history of intrauterine exposure to ampicillin in the immediate prenatal period than infants who did not develop NEC.
Publisher
Journal of Childrens Infections
Reference26 articles.
1. Henry MCW, Moss L. Neonatal necrotizing enterocolitis. Semin Pediatr Surg, 2008; 17: 98—109.
2. Luig M., Lui K. Epidemiology of necrotizing enterocolitis—Part II: risks and susceptibility of premature infants during the surfactant era. J Pediatr Child Health, 2005; 41:1 74—9.
3. Kucherov Yu.I., Zhirkova Yu.V., Shishkina T.N., Mikhalev I.A., Arsa A.V, Chebotaeva L.I. Diagnostics and treatment of necrotizing enterocolitis in premature infants. Rossiyskiy Vestnik Perinalologii i Pediatrii=Rus-sian Bulletin of Perinatology and Pediatrics. 2014; 59(6):18—24. (In Russ.)
4. Lin P.W., Nasr T.R., Stoll B.J. Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention. Semin Perinatol, 2008; 32: 70—82.
5. Lin P.W., Stoll B.J. Necrotising enterocolitis. Lancet, 2006; 368: 1271—83.