Severe forms of hereditary spherocytosis in children with congenital active cytomegalovirus infection

Author:

Komarova A. A.1ORCID,Sarkisyan H. A. H. A.2ORCID,Khokhlova A. P.1ORCID,Polyak E. A.1ORCID,Vershinnikova V. A.1ORCID,Baltaeva K. R.1ORCID,Kantserova D. R.1ORCID,Mironova V. A.1ORCID,Makarova L. M.3,Belaya A. L.3,Atapina A. E.3ORCID,Lyubeznova I. G.3ORCID

Affiliation:

1. Pirogov Russian National Research Medical University of the Ministry of Health

2. Pirogov Russian National Research Medical University of the Ministry of Health; Children’s City Clinical Hospital No. 9 named after G.N. Speransky

3. Children’s City Clinical Hospital No. 9 named after G.N. Speransky

Abstract

Congenital cytomegalovirus (CMV) infection is the cause of fetal malformations, fetal death, severe generalized disease up to death, and changes in hematopoiesis. It should be noted that the pantropic effects of the virus and the peculiarities of the immunopathogenesis of congenital CMV infection are often the basis for the occurrence of autoimmune diseases Also CMV can be the reason in decompensation of combined pathologies. Below are two cases of severe hereditary sphero-cytosis in children with congenital active CMV infection.

Publisher

Journal of Childrens Infections

Reference20 articles.

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2. Clinical recommendations of the Russian Society of Neonatologists together with the Russian Association of Perinatal Medicine Specialists: «Congenital cytomegalovirus infection», project 2023. (In Russ.)

3. Аvery’s diseases of the newborn, Еleventh edition. ISBN: 978-0-323- 82823-9 Copyright © 2023— 2024 by Elsevier

4. Enders G., Daiminger A., Bäder U., Exler S, Enders M. Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age. J Clin Virol. 2011. DOI:10.1016/j.jcv.2011.07.005

5. Kholodnova N.V., L.N. Mazankova, A.A. Voltеr, I.E. Turina. A modern view of the problem of congenital cytomegalovirus infection. Detskie Infektsii = Children's Infections. 2019; 18(3):46—52. (In Russ.) doi.org/10.22627/2072-8107-2019-18-3-46-52

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