Author:
Kober Christina,Manni Sandro,Wolff Svenja,Barnes Thomas,Mukherjee Shatanik,Vogel Thomas,Hoenig Lea,Vogel Peter,Hahn Aaron,Gerlach Michaela,Vey Martin,Widmer Eleonora,Keiner Björn,Schuetz Patrick,Roth Nathan,Kalina Uwe
Abstract
Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247–567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to Spike-1 protein and the receptor-binding domain correlates strongly with viral neutralization in vitro. Furthermore, despite accounting for only approximately 12% of total immunoglobulin mass, collectively IgG3 and IgM account for approximately 80% of the total neutralization. This may have important implications for the development of potent therapies for COVID-19, as it indicates that hyperimmune globulins or convalescent plasma donations with high IgG3 concentrations may be a highly efficacious therapy.
Publisher
Public Library of Science (PLoS)
Cited by
23 articles.
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