Abstract
Background
Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).
Objective
To describe the clinical characteristics of patients with ARDS-COVID-19.
Materials and methods
This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C‐reactive protein (CRP)], thrombotic activity (D‐dimer) and serum ferritin and lactate dehydrogenase (LDH).
Results
The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.
Conclusion
COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
Publisher
Public Library of Science (PLoS)
Reference25 articles.
1. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19;Y Gao;J Med Virol,2020
2. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China;DS Hui;Int J Infect Dis,2020
3. Coronavirus Infections-More Than Just the Common Cold;CI Paules;JAMA—J Am Med Assoc,2020
4. Wan S, Yi Q, Fan S, Lv J, Zhang X, Guo L, et al. Title page 1 Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized 2 patients with 2019 novel coronavirus pneumonia (NCP) 3 n.d. https://doi.org/10.1101/2020.02.10.20021832.
5. Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China;Y Shang;Ann Intensive Care,2020
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