Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy-Reference-Cited by-同舟云学术

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Published:2016-09-09 Issue:9 Volume:11 Page:e0162162
ISSN:1932-6203
Container-title:PLOS ONE
language:en
Short-container-title:PLoS ONE

Author:

Enoru Julius O.,Yang Barbara,Krishnamachari Sesha,Villanueva Ernesto,DeMaio William,Watanyar Adiba,Chinnasamy Ramesh,Arterburn Jeffrey B.,Perez Ruth G.

Funder

Lizanell and Colbert Coldwell Foundation

Texas Tech University

Hoy Family Research

Anna Mae Doyle Gift Funds

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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1. Preclinical Validation of FTY720 and FTY720-Mitoxy in Mouse Models of Parkinsons Disease and Multiple System Atrophy (MSA): Evidence for Treating Lewy Body Disease Synucleinopathies Including MSA;Rare Neurodegenerative Disorders - New Insights [Working Title];2024-05-23

2. Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease;International Journal of Molecular Sciences;2021-06-11

3. FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models;Experimental Neurology;2020-03

4. A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models;Journal of Parkinson's Disease;2020-01-13

5. FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures;Neuropharmacology;2019-11