Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome
Author:
Funder
National Institutes of Health
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference27 articles.
1. Molecular mechanisms of fragile X syndrome: a twenty-year perspective;MR Santoro;Annual review of pathology,2012
2. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome;AJ Verkerk;Cell,1991
3. Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus;RS Alisch;BMC medical genetics,2013
4. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells;B Coffee;Nature genetics,1999
5. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome;R Biacsi;PLoS genetics,2008
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