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Optimizing Trial Designs for Targeted Therapies

  • Published:2016-09-29 Issue:9 Volume:11 Page:e0163726
  • ISSN:1932-6203
  • Container-title:PLOS ONE
  • language:en
  • Short-container-title:PLoS ONE

Author:

Ondra Thomas,Jobjörnsson Sebastian,Beckman Robert A.,Burman Carl-Fredrik,König Franz,Stallard Nigel,Posch Martin

Funder

Directorate-General for Research and Innovation

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference30 articles.

1. Clinical Trial Designs for Predictive Biomarker Validation: One Size Does Not Fit All;SJ Mandrekar;Journal of Biopharmaceutical Statistics,2009

2. Hypothesis Testing in a Confirmatory Phase III Trial With a Possible Subset Effect;C Chen;Statistics in Biopharmaceutical Research,2009

3. Randomized Clinical Trials With Biomarkers: Design Issues;B Freidlin;JNCI Journal of the National Cancer Institute,2010

4. Design of clinical trials for biomarker research in oncology;SJ Mandrekar;Clinical Investigation,2011

5. Randomized Phase II Trial Designs With Biomarkers;B Freidlin;Journal of Clinical Oncology,2012

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