Abstract
Background
People living with HIV (PLHIV) in resource-limited settings are vulnerable to malnutrition. Nutritional interventions aimed at improving food insecurity and malnutrition, together with antiretroviral therapy (ART), could improve treatment outcomes. In Nigeria, there is a high awareness of the nutraceutical benefits of Moringa oleifera. Thus, this study aimed to evaluate the effects of Moringa oleifera leaf supplementation on the CD4 counts, viral load and anthropometric of HIV-positive adults on ART.
Methods
This was a double-blind, randomized study. Two hundred HIV-positive patients were randomly allocated to either the Moringa Oleifera group (MOG) given Moringa oleifera leaf powder or the control group (COG) given a placebo. Changes in anthropometric parameters [weight; body mass index (BMI)] and CD4 cell counts were measured monthly for six months, while HIV-1 viral loads were measured at baseline and the end of the study for both groups.
Results
Over the study period, the treatment by time interaction shows a significant difference in CD4 counts by treatment group (p<0.0001). A further estimate of fixed effects showed that the CD4 counts among MOG were 10.33 folds greater than COG over the study period. However, the viral load (p = 0.9558) and all the anthropometric parameters (weight; p = 0.5556 and BMI; p = 0.5145) between the two groups were not significantly different over time. All tests were conducted at 95CI.
Conclusion
This study revealed that Moringa oleifera leaf supplementation was associated with increased CD4 cell counts of PLHIV on ART in a resource-limited setting. Programs in low-resource settings, such as Nigeria, should consider nutritional supplementation as part of a comprehensive approach to ensure optimal treatment outcomes in PLHIV.
Funder
Department of Science and Innovation of South Africa
College of Health Sciences, University of Kwazulu-Natal, Durban, South Africa
Publisher
Public Library of Science (PLoS)
Reference37 articles.
1. UNAIDS. Press release. New survey results indicate that Nigeria has an HIV prevalence of 1.4%. Available: https://wwwunaidsorg/en/resources/presscentre/pressreleaseandstatementarchive/2019/march/20190314_nigeria. 2019. [Accessed 2021 August 28].
2. Avert. HIV and AIDS in Nigeria. Available: https://wwwavertorg/professionals/hiv-around-world/sub-saharan-africa/nigeria. 2019. [Accessed 2021 August 28].
3. UNAIDS. UNAIDS Data. Available: https://wwwunaidsorg/sites/default/files/media_asset/unaids-data-2018_enpdf. 2018. [Accessed 2021 August 28].
4. UNAIDS. Fact Sheet–Global AIDS update UNAIDS. Available: https://wwwunaidsorg/sites/default/files/media_asset/UNAIDS_FactSheet_enpdf. 2019. [Accessed 2021 August 28].
5. Reduced economic burden of AIDS-defining illnesses associated with adherence to antiretroviral therapy.;H-S Toh;Int J Infec Dis,2020
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献