Abstract
Background
At the end of 2019, there were about 2.8 million children and adolescents aged 0–19 living with HIV. In contrast to pregnant women and adults, service delivery for children and adolescents living with HIV continues to lag behind with regard to access to care, components of care delivery, treatment options, and clinical and immunologic outcomes.
Aim
The aim of this systematic review is to synthesize the evidence on the most effective interventions, models, programs, and strategies to optimize the delivery of services for the testing, linkage, treatment and retention of children and adolescents living with HIV globally.
Methods
This review protocol is registered at PROSPERO with Registration number: CRD42020209553. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We will use a comprehensive search strategy to search several bibliographic databases including MEDLINE, Embase, CINAHL, Cochrane Library, Global Health, and Psycinfo to identify relevant studies published in the last ten years (2010 to 2020). In addition, we will review cited and citing references of included studies. A pair of reviewers will independently screen titles, abstracts and full texts of articles, extract data from articles meeting inclusion criteria and perform quality assessments of the evidence collected. We will conduct a narrative synthesis of our findings, and if there are sufficient clinically similar studies available, we will conduct meta-analysis using a random-effects model.
Discussion
This review will provide evidence on service delivery models that have been evaluated in a range of settings to efficiently and effectively locate, link, treat and retain in care, children and adolescents living with HIV. The synthesized evidence will help guide national governments and health care providers in prioritizing and adopting evidence-based service delivery approaches for children and adolescents living with HIV.
Systematic review registration
PROSPERO CRD42020209553.
Funder
Fogarty International Center
National Institute of Child Health and Human Development
Publisher
Public Library of Science (PLoS)
Reference39 articles.
1. Joint United Nations Programme on HIV/AIDS (UNAIDS) Global AIDS Monitoring 2020. UNAIDS epidemiological estimates 2020. [cited 2020 Dec 01]. Available from: https://data.unicef.org/topic/hivaids/emtct/
2. Joint United Nations Programme on HIV/AIDS (UNAIDS) Global AIDS Monitoring 2020. UNAIDS epidemiological estimates 2020. [cited 2020 Dec 01]. Available from: https://data.unicef.org/topic/hivaids/global-regional-trends/
3. Joint United Nations Programme on HIV/AIDS (UNAIDS) Global AIDS Monitoring 2020. UNAIDS epidemiological estimates, 2020. [cited 2020 Dec 01]. Available from: https://data.unicef.org/topic/hivaids/paediatric-treatment-and-care/
4. 2020 World AIDS Day Report. Reimagining a resilient HIV response for children, adolescents and pregnant women living with HIV;United Nations Children’s Fund (UNICEF).,2020
5. Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive;Joint United Nations Programme on HIV/AIDS (UNAIDS).,2011
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献