Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques
Author:
Dudley Dawn M.ORCID, Koenig Michelle R., Stewart Laurel M., Semler Matthew R., Newman Christina M., Shepherd Phoenix M., Yamamoto Keisuke, Breitbach Meghan E., Schotzko Michele, Kohn Sarah, Antony Kathleen M., Qiu Hongyu, Tunga Priyadarshini, Anderson Deborah M., Guo Wendi, Dennis Maria, Singh Tulika, Rybarczyk SierraORCID, Weiler Andrea M., Razo Elaina, Mitzey Ann, Zeng Xiankun, Eickhoff Jens C., Mohr Emma L.ORCID, Simmons Heather A., Fritsch Michael K., Mejia Andres, Aliota Matthew T.ORCID, Friedrich Thomas C.ORCID, Golos Thaddeus G., Kodihalli Shantha, Permar Sallie R., O’Connor David H.
Abstract
There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.
Funder
National Institute of Allergy and Infectious Diseases NIH Office of the Director National Institutes of Health
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference51 articles.
1. Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure—U.S. Zika Pregnancy Registry, 2016;MR Reynolds;MMWR Morb Mortal Wkly Rep.,2017 2. Pregnancy Outcomes After Maternal Zika Virus Infection During Pregnancy—U.S. Territories, January 1, 2016-April 25, 2017;CK Shapiro-Mendoza;MMWR Morb Mortal Wkly Rep.,2017 3. Zika epidemiology update;World Health Organization;World Health Organization Emergencies [Internet],2019 4. Zika Virus Seropositivity in 1-4-Year-Old Children, Indonesia, 2014;RT Sasmono;Emerg Infect Dis,2018 5. Low Zika Virus Seroprevalence in Vientiane, Laos, 2003–2015;B Pastorino;Am J Trop Med Hyg,2019
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