COVID-19 cross-sectional study in Maricá, Brazil: The impact of vaccination coverage on viral incidence
Author:
Frauches Thiago Silva, Costa Carlos Alberto de Senna, Rodrigues Claudia dos Santos, de Azevedo Marcelo Costa Velho Mendes, Ferreira Michelle de Moraes, Ramos Hanna Beatriz Vieira da Silva, de Souza Junior Wilson Rodrigues, Costa Andréa Ribeiro, Camargo Adriana Cardoso, Alonso Adriana Halfeld, dos Santos Fábio Álvaro, Oliveira Hércules da Silva, Coelho Janaína Guimarães, Sobral Joyce Florentina da Silva, Rodrigues Luciane Cardoso dos Santos, Ferreira Marcio Martins Casaes, Laureano Patricia, da Paz Fernandes Raquel Adalgiza, Santos Renata da Silva, dos Santos Rose Mary Carvalho, Milagres Sanderson, dos Santos Vanessa Cristina Conceição, Silva Jussara Teixeira, da Silva Tatiana Martins, da Rocha Malu Gabriela Costa, de São Carlos Andreia Edwirges, de Araújo Ramos Amorim Mourão, Bastos Fernanda Martins de Almeida, Francisco Daina Raylle, Rosa Sabrina dos Santos, Linhares Layla Corrêa, Organista Raissa Rodrigues, Bastos Leandro, Pinto Maria Magdalena Kelly, do Nascimento Jean Pablo Lima, da Silveira João Pedro Moura, dos Santos Mateus Quintanilha, da Silva Nathaly Santos, Ferreira Nayra Cristina dos Santos, Reis Rafael Brito Ramirez, de Oliveira Ruan Fonseca, Sá Valdinei de Oliveira, Hammes Thyago Ramos de Siqueira, Monteiro Juliano de Oliveira, Cardoso Pedro Henrique, Arruda Mônica Barcellos, Alvarez Patricia, Maia Richard Araujo, Ribeiro Liane de Jesus, Ferreira Orlando Costa, Santos Aline, de Almeida Alberto Carlos Melo, Garcia Lauro, Pansera Celso, Tanuri AmilcarORCID
Abstract
Population surveillance in COVID-19 Pandemic is crucial to follow up the pace of disease and its related immunological status. Here we present a cross-sectional study done in Maricá, a seaside town close to the city of Rio de Janeiro, Brazil. Three rounds of study sampling, enrolling a total of 1134 subjects, were performed during May to August 2021. Here we show that the number of individuals carrying detectable IgG antibodies and the neutralizing antibody (NAb) levels were greater in vaccinated groups compared to unvaccinated ones, highlighting the importance of vaccination to attain noticeable levels of populational immunity against SARS-CoV-2. Moreover, we found a decreased incidence of COVID-19 throughout the study, clearly correlated with the level of vaccinated individuals as well as the proportion of individuals with detectable levels of IgG anti-SARS-CoV-2 and NAb. The observed drop occurred even during the introduction of the Delta variant in Maricá, what suggests that the vaccination slowed down the widespread transmission of this variant. Overall, our data clearly support the use of vaccines to drop the incidence associated to SARS-CoV-2.
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference45 articles.
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