Abstract
BackgroundThe predictive role of hematological indexes of mean platelet volume (MPV) and red cell distribution width (RDW) has been demonstrated in cardiovascular disease concomitant with psoriasis. This meta-analysis is intended to assess whether MPV and RDW can also serve as biomarkers for the early diagnosis and disease severity assessment of psoriasis.Material and methods13 studies which enrolled 1331 psoriasis patients and 919 healthy volunteers were included after screening the search results from PubMed, Embase and the Cochrane Library since inception to Mar 14, 2020. MPV of psoriasis participants and their counterparts was assessed in 10 studies, and RDW was evaluated in 4 studies, while the disease severity was measured by the Psoriasis Area and Severity Index (PASI) in 11 studies. Random-effect model analysis was applied to calculate pooled standard mean difference (SMD) with 95% confidence interval (95% CI).ResultsAssociations of MPV and RDW with the presence of psoriasis were demonstrated (MPV: SMD = 0.503, 95% CI: 0.242–0.765; RDW: SMD = 0.522, 95% CI: 0.228–0.817), but no statistically significant correlation of MPV and disease severity of psoriasis was found in meta-regression analysis (p = 0.208). Subgroup analysis revealed that the diagnosis value of MPV and RDW was consistent regardless of PASI and study type. Heterogeneity analysis between studies was implemented by chi-squared test andI2statistics. Begg’s and Egger’s test were utilized for the evaluation of publication bias. The sensitivity analysis revealed no significant alteration no matter which study was excluded.ConclusionMPV and RDW could serve as promising predictive diagnostic biomarkers of psoriasis.
Funder
National Natural Science Foundation of China
Key Research and Development Project of Hainan Province
Natural Science Foundation of Hainan Province
Hunan Talent Young Investigator
Hunan Outstanding Young Investigator
Hainan Province Clinical Medical Center
Publisher
Public Library of Science (PLoS)
Reference50 articles.
1. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review;AW Armstrong;Jama,2020
2. Psoriasis;JE Greb;Nature reviews Disease primers,2016
3. Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis;K Yadav;International journal of biological macromolecules,2018
4. Multicomponent Biomarker Approach Improves the Accuracy of Diagnostic Biomarkers for Psoriasis Vulgaris;E Reimann;Acta dermato-venereologica,2019
5. Prediction of crucial epigenetically‑associated, differentially expressed genes by integrated bioinformatics analysis and the identification of S100A9 as a novel biomarker in psoriasis;X Wang;International journal of molecular medicine,2020
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