THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy

Author:

Díaz-Herrero M. Mar,del Campo José A.,Carbonero-Aguilar Pilar,Vega-Pérez José M.,Iglesias-Guerra Fernando,Periñán Ignacio,Miñano Francisco J.,Bautista Juan,Romero-Gómez Manuel

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference33 articles.

1. Microglia activation in hepatic encephalopathy in rats and humans;I Zemtsova;Hepatology,2011

2. Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations. Metab Brain Dis;M Llansola,2013

3. Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats. J Hepatol;M Jover-Cobos,2014

4. Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake;G Dam;Hepatology,2013

5. New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects. Gastroenterol Hepatol;M Romero-Gómez,2004

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