Thrombophilia genetic mutations and their relation to disease severity among patients with COVID-19

Author:

Moness Hend,Mousa Suzan Omar,Mousa Sarah Omar,Adel Nashwa Mohamed,Ibrahim Reham Ali,Hassan Ebtesam Esmail,Abdelhameed Nadia Ismail,Meshref Dalia Abdelrahman,Abdullah Noha M.ORCID

Abstract

Objectives Patients with COVID-19 infection appear to develop virus-induced hypercoagulability resulting in numerous thrombotic events. The aim of the present study was to determine the relationship between the thrombophilia genes mutations (prothrombin G20210A, factor V Leiden, and methyltetrahydrofolate reductase (MTHFR)) and the severity of COVID-19 patients. Design Prospective cross-sectional study. Method One hundred and forty patients (80 adults and 60 children) were included in the current study. They were divided into the severe COVID-19 group and the mild COVID-19 group, with each group comprising 40 adults and 30 children. The patients were assessed for FV R506Q, FV R2H1299R, MTHFR A1298C, MTHFR C677T, and prothrombin gene G20210A polymorphisms. CBC, D-dimer, renal and liver function tests, hs-CRP, ferritin, and LDH were also assessed. Thrombotic events were clinically and radiologically documented. Results Severe COVID-19 cases were significantly more frequent to have a heterozygous mutation for all the studied genes compared to mild COVID-19 cases (p<0.05 for all). Being mutant to gene FV R506Q carried the highest risk of developing a severe disease course (p<0.0001). Patients with abnormally high D-dimer levels were significantly more frequent to be heterozygous for FV R506Q, FV R2H1299R, and prothrombin gene G20210A (p = 0.006, 0.007, and 0.02, respectively). Conclusion We concluded that there is an evident relationship between severe COVID-19 and inherited thrombophilia. In the current study, FV R506Q gene mutation carried the highest risk of developing a severe COVID-19 disease course.

Publisher

Public Library of Science (PLoS)

Reference55 articles.

1. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle;H Lu;J Med Virol,2020

2. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China;DS Hui;International Journal of Infectious Diseases,2020

3. Severe acute respiratory syndrome-related coronavirus: The species and its viruses—a statement of the Coronavirus Study Group;AE Gorbalenya;bioRxiv,2020

4. Coronavirus in China;TK Burki;The Lancet Respiratory Medicine,2020

5. The epidemiology and therapeutic options for the COVID-19;J Li;Precis Clin Med,2020

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