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Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

  • Published:2018-05-22 Issue:5 Volume:13 Page:e0197173
  • ISSN:1932-6203
  • Container-title:PLOS ONE
  • language:en
  • Short-container-title:PLoS ONE

Author:

Tobias Andrew M.,Toska Dea,Lange Keith,Eck Tyler,Bhat Rohit,Janson Cheryl A.,Rotella David P.,Gubler Ueli,Goodey Nina M.ORCID

Funder

American Society of Biochemistry and Molecular Biology (ASBMB) Undergraduate Research Award

Montclair State University Science Honors Innovation Program (SHIP)

American Society of Biochemistry and Molecular Biology (ASBMB)

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference21 articles.

1. Organization WH. Lymphatic Filariasis Fact Sheet 2017, viewed July 13, 2017, http://www.who.int/mediacentre/factsheets/fs102/en/.

2. Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease;KD Ramaiah;PLoS Negl Trop Dis,2015

3. Development of a fluorescently labeled thermostable DHFR for studying conformational changes associated with inhibitor binding;NM Goodey;Biochem Biophys Res Commun,2011

4. Allosteric regulation and catalysis emerge via a common route;NM Goodey;Nat Chem Biol,2008

5. Life without dihydrofolate reductase FolA;H Myllykallio;Trends Microbiol,2003
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