Computer simulations reveal changes in the conformational space of the transcriptional regulator MosR upon the formation of a disulphide bond and in the collective motions that regulate its DNA-binding affinity

Author:

Câmara Amanda Souza,Horjales EduardoORCID

Funder

FAPESP

CNPq

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference35 articles.

1. Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance;J Pieters;Cell Host Microbe,2008

2. The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis;P Brugarolas;J Biol Chem,2012

3. Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins;SP Wilkinson;Curr Issues Mol Biol,2006

4. Winged helix proteins;KS Gajiwala;CurrOpinStruct Biol,2000

5. Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa;D Lim;J Biol Chem,2002

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