Abstract
Objective
This study aimed to determine the prevalence of vertebral fractures (VF) in a selected urban population in Malaysia and to explore possible variables associated with VF in the study population.
Methods
A cross-sectional study involving community-living, healthy subjects aged between 45–90 years from the state of Selangor, Malaysia, were invited to attend a bone health check-up. Subjects with diseases known to affect bone metabolism or were on treatment for osteoporosis (OP) were excluded. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Lateral and antero-posterior view lumbar spine x-rays were performed and VF was determined by the semi-quantitative Genant method.
Results
A total of 386 subjects were studied. Asymptomatic morphometric VF were found in 44 (11.4%) subjects. T12 was the most common vertebrae to be fractured. The prevalence of VF was significantly higher in menopausal women (12.4%) compared to non-menopausal women, in those above the age of 60 (18.5%), in those of Chinese ethnicity (16.5%), in those with a low body fat percentage (17.1%) and among those with OP (27.0%). The mean (standard deviation) 25-hydroxyvitamin D [25(OH)D] levels were significantly higher in those with VF compared to those without VF, 67.64 (23.50) and 57.47 (21.71) nmol/L, respectively. However, after multiple regression analysis, age over 60 years and OP on DXA BMD measurement were the only significant associated factors for VF.
Conclusion
Overall, 11.4% of a selected Malaysian urban population had asymptomatic morphometric VF. Age over 60 years and OP on DXA BMD measurement, but not 25(OH)D levels, were associated with VF.
Funder
Ministry of Education, Malaysia
Publisher
Public Library of Science (PLoS)
Reference38 articles.
1. Osteoporosis prevention, diagnosis, and therapy;NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy;JAMA,2001
2. Vertebral Fractures: Clinical Importance and Management;DL Kendler;Am J Med,2016
3. Worldwide prevalence and incidence of osteoporotic vertebral fractures;G Ballane;Osteoporos Int,2017
4. Prevalence of vertebral fracture in Asian men and women: comparison between Hong Kong, Thailand, Indonesia and Japan;AW Kwok;Public Health,2012
5. The prevalence of vertebral deformity in European men and women: the European Vertebral Osteoporosis Study;TW O’Neill;J Bone Miner Res,1996
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