Classifying muscle parameters with artificial neural networks and simulated lateral pinch data

Abstract

Objective Hill-type muscle models are widely employed in simulations of human movement. Yet, the parameters underlying these models are difficult or impossible to measure in vivo. Prior studies demonstrate that Hill-type muscle parameters are encoded within dynamometric data. But, a generalizable approach for estimating these parameters from dynamometric data has not been realized. We aimed to leverage musculoskeletal models and artificial neural networks to classify one Hill-type muscle parameter (maximum isometric force) from easily measurable dynamometric data (simulated lateral pinch force). We tested two neural networks (feedforward and long short-term memory) to identify if accounting for dynamic behavior improved accuracy. Methods We generated four datasets via forward dynamics, each with increasing complexity from adjustments to more muscles. Simulations were grouped and evaluated to show how varying the maximum isometric force of thumb muscles affects lateral pinch force. Both neural networks classified these groups from lateral pinch force alone. Results Both neural networks achieved accuracies above 80% for datasets which varied only the flexor pollicis longus and/or the abductor pollicis longus. The inclusion of muscles with redundant functions dropped model accuracies to below 30%. While both neural networks were consistently more accurate than random guess, the long short-term memory model was not consistently more accurate than the feedforward model. Conclusion Our investigations demonstrate that artificial neural networks provide an inexpensive, data-driven approach for approximating Hill-type muscle-tendon parameters from easily measurable data. However, muscles of redundant function or of little impact to force production make parameter classification more challenging.