Abstract
Essential genes, which form the basis of life activities, are crucial for the survival of organisms. Essential genes tend to be located in operons, but how they are distributed in operons is still unclear for most prokaryotes. In order to clarify the general rule of position preference of essential genes in operons, an index of the average position of genes in an operon was proposed, and the distributions of essential and non-essential genes in operons in 51 bacterial genomes and two archaeal genomes were analyzed based on this new index. Consequently, essential genes were found to preferentially occupy the front positions of the operons, which tend to be expressed at higher levels.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Publisher
Public Library of Science (PLoS)
Reference43 articles.
1. Emerging and evolving concepts in gene essentiality;G Rancati;Nature Reviews Genetics,2018
2. How many genes can make a cell: the minimal-gene-set concept;EV Koonin;Annual review of genomics and human genetics,2000
3. Human gene essentiality;I Bartha;Nature Reviews Genetics,2018
4. Essential Bacillus subtilis genes;K Kobayashi;Proceedings of the National Academy of Sciences,2003
5. An estimation of minimal genome size required for life;M Itaya;FEBS letters,1995
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献