Abstract
Background
Early infant HIV diagnosis (EID) is critical to ensuring timely diagnosis of HIV-exposed infants, and treatment in those found to be infected. However estimates of coverage vary considerably, depending on data sources used. We used 4 methods to estimate coverage among a historical cohort of HIV-exposed infants in rural South Africa, between 2010–2016.
Methods
We estimated the proportion of infants ever tested (methods 1–3) and tested by 7 weeks of age (1–4) as follows: (1) infants born to women identified as HIV-positive in demographic surveillance were linked to those with ≥1 EID result in routine laboratory surveillance; (2) the number of infants with ≥1 EID result in laboratory surveillance divided by the estimated number of HIV-exposed infants, calculated as total live births multiplied by antenatal HIV seroprevalence; (3) the number of infants with ≥1 EID result in routine laboratory surveillance, divided by the number of HIV-exposed infants as estimated by the district health service; (4) from documentation in infants’ Road-to-Health-booklets.
Results
The proportion ever tested was 43%, 88% and 138% for methods 1–3, and by 7 weeks of age was 25%, 49%, 86% and 46% for methods 1–4 respectively.
Conclusions
The four methods, applied to a range of routine data sources, resulted in estimates varying considerably, and the true coverage of EID remains unclear. Our findings highlight the importance of developing unique patient identifiers, improving training of healthcare providers using reporting systems, and ensuring the accuracy of healthcare records, to ensure the best possible health outcomes for HIV-exposed infants.
Funder
Medical Research Council
Wellcome Trust
FP7 People: Marie-Curie Actions
Department for International Development
NIHR GOSH BRC
Publisher
Public Library of Science (PLoS)
Reference32 articles.
1. Progress towards the 2020 targets for HIV diagnosis and antiretroviral treatment in South Africa;L.F. Johnson;South African Journal of HIV Medicine,2017
2. UNAIDS. Global AIDS Update 2017 (http://aidsinfo.unaids.org/). 2017 Accessed: 28th July 2017].
3. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis;M.L. Newell;Lancet,2004
4. Laboratory information system data demonstrate successful implementation of the prevention of mother-to-child transmission programme in South Africa;G.G. Sherman;South African Medical Journal,2014