Report: The effects of topical pleurotus tuberregium (PT) aqueous extract on intraocular pressure in monkeys

Author:

Akinlabi Ghalib A.ORCID,Kaufman Paul L.,Kiland Julie A.

Abstract

Purpose In earlier experiments in Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model. The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates. Methods Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3). The monkeys were sedated with 5–10 mg/kg ketamine HCl IM. PT was administered to the right eye and BSS to the left eye. Baseline IOP was measured just prior to beginning treatment, and on day 5 before treatment and then hourly for 3 hours, beginning 1 hour after treatment. SLEs were performed at baseline and on day 5 pre- and 3 hours post-treatment. Results There was no significant difference between IOP in treated vs control eyes in the protocol. There were no adverse effects or toxicity as seen by SLE. Conclusions The inability of the extract to lower IOP in monkeys, in contrast to ocular hypertensive cats in an earlier study, could be due to species differences or duration of treatment. Since no adverse effects were observed in the monkeys, further studies with varying durations and dosages are recommended.

Funder

Nigerian tertiary education trust fund

Research to Prevent Blindness, New York

NIH/NEI (Core Grant for Vision Research

Ocular Physiology Research & Education Foundation

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference44 articles.

1. Pleurotus tuberregium from Nigeria;BA Oso;Mycologia,1977

2. Vilgalys R, Moncalvo JM, Liou SR, Volovsek M. Recent advances in molecular systematics of the genus Pleurotus. In Royse, D.J. (PDF). Mushroom biology and mushroom products: proceedings of the 2nd International Conference. June 9–12, 1996.

3. Isikhuemhen OS, Okhuoya JA. Cultivation of Pleurotus tuber-regium for production of edible sclerotia on agricultural wastes. In Royse, D.J. (PDF). Mushroom biology and mushroom products: proceedings of the 2nd International Conference, June 9–12, 1996.

4. Tropical Macrofungi

5. Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects;K Khatun;Mymen. Med. J,2007

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3