A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation In Vivo and Regulates Urethral Tension

Author:

Saga Hiroshi,Ohhata Akira,Hayashi Akio,Katoh Makoto,Maeda Tatsuo,Mizuno Hirotaka,Takada Yuka,Komichi Yuka,Ota Hiroto,Matsumura Naoya,Shibaya Masami,Sugiyama Tetsuya,Nakade Shinji,Kishikawa Katsuya

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference36 articles.

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2. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases;J Murata;J Biol Chem,1994

3. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production;M Umezu-Goto;J Cell Biol,2002

4. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase;A Tokumura;J Biol Chem,2002

5. Structural basis of substrate discrimination and integrin binding by autotaxin;J Hausmann;Nat Struct Mol Biol,2011

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