The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor-Reference-Cited by-同舟云学术

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The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

Published:2014-03-24 Issue:3 Volume:9 Page:e92727
ISSN:1932-6203
Container-title:PLoS ONE
language:en
Short-container-title:PLoS ONE

Author:

Miller-Gallacher Jennifer L.,Nehmé Rony,Warne Tony,Edwards Patricia C.,Schertler Gebhard F. X.,Leslie Andrew G. W.,Tate Christopher G.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference66 articles.

1. The structure and function of G-protein-coupled receptors;DM Rosenbaum;Nature,2009

2. Molecular signatures of G-protein-coupled receptors;AJ Venkatakrishnan;Nature,2013

3. Engineering G protein-coupled receptors to facilitate their structure determination;CG Tate;Curr Opin Struct Biol,2009

4. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor;V Cherezov;Science,2007

5. Two distinct conformations of helix 6 observed in antagonist-bound structures of a {beta}1-adrenergic receptor;R Moukhametzianov;Proc Natl Acad Sci U S A,2011

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