Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density
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Published:2020-12-28
Issue:12
Volume:16
Page:e1009190
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ISSN:1553-7404
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Container-title:PLOS Genetics
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language:en
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Short-container-title:PLoS Genet
Author:
Swan Anna L.ORCID, Schütt Christine, Rozman JanORCID, del Mar Muñiz Moreno MariaORCID, Brandmaier Stefan, Simon Michelle, Leuchtenberger StefanieORCID, Griffiths Mark, Brommage RobertORCID, Keskivali-Bond Piia, Grallert HaraldORCID, Werner ThomasORCID, Teperino RaffaeleORCID, Becker LoreORCID, Miller GregorORCID, Moshiri Ala, Seavitt John R.ORCID, Cissell Derek D.ORCID, Meehan Terrence F., Acar Elif F.ORCID, Lelliott Christopher J.ORCID, Flenniken Ann M., Champy Marie-France, Sorg Tania, Ayadi Abdel, Braun Robert E.ORCID, Cater HeatherORCID, Dickinson Mary E., Flicek PaulORCID, Gallegos Juan, Ghirardello Elena J.ORCID, Heaney Jason D.ORCID, Jacquot Sylvie, Lally ConnorORCID, Logan John G.ORCID, Teboul Lydia, Mason JeremyORCID, Spielmann Nadine, McKerlie Colin, Murray Stephen A., Nutter Lauryl M. J.ORCID, Odfalk Kristian F.ORCID, Parkinson Helen, Prochazka JanORCID, Reynolds Corey L., Selloum MohammedORCID, Spoutil FrantisekORCID, Svenson Karen L.ORCID, Vales Taylor S.ORCID, Wells Sara E.ORCID, White Jacqueline K.ORCID, Sedlacek RadislavORCID, Wurst WolfgangORCID, Lloyd K. C. KentORCID, Croucher Peter I., Fuchs Helmut, Williams Graham R.ORCID, Bassett J. H. Duncan, Gailus-Durner Valerie, Herault YannORCID, Mallon Ann-Marie, Brown Steve D. M.ORCID, Mayer-Kuckuk Philipp, Hrabe de Angelis MartinORCID,
Abstract
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored BMD pathways, including vesicle transport, in these cells and together with in silico bone turnover studies resulted in the prioritization of candidate genes for further investigation. Overall, the results add novel pathophysiological and molecular insight into bone health and disease.
Publisher
Public Library of Science (PLoS)
Subject
Cancer Research,Genetics(clinical),Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics
Cited by
22 articles.
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