DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans
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Published:2021-06-11
Issue:6
Volume:17
Page:e1009618
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ISSN:1553-7404
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Container-title:PLOS Genetics
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language:en
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Short-container-title:PLoS Genet
Author:
Hong HuiORCID,
Chen Huicheng,
Zhang Yuxia,
Wu Zhimao,
Zhang Yingying,
Zhang Yingyi,
Hu Zeng,
Zhang Jian V.,
Ling Kun,
Hu Jinghua,
Wei QingORCID
Abstract
Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted protein. Further investigations revealed that DYF-4 interacts with DAF-6 and functions in a same pathway as DAF-6 to regulate sensory compartment formation. Furthermore, we demonstrated that reported glial suppressors of daf-6 could also restore dendrite elongation and ciliogenesis in both dyf-4 and daf-6 mutants. Collectively, our data reveal that DYF-4 is a regulator for DAF-6 which promotes the proper formation of the glial channel and indirectly affects neurite extension and ciliogenesis.
Funder
National Natural Science Foundation Youth Project of China
National Natural Science Foundation of China
Publisher
Public Library of Science (PLoS)
Subject
Cancer Research,Genetics(clinical),Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics
Cited by
1 articles.
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