HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?

Author:

Guibinga Ghiabe-Henri,Murray Fiona,Barron Nikki

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference49 articles.

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2. Jinnah HA, Friedmann T (2000) Lesch-Nyhan Disease and its variants. In: Scriver C, Beaudet, AL, Sly WS, Valle, D., editor. The Metabolic and Molecular bases of inherited disease. 8 ed ed: McGraw-Hill. 2537–2570.

3. Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis;I Ceballos-Picot;Hum Mol Genet,2009

4. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis;GH Guibinga;Mol Ther,2010

5. Human neural stem cells: a model system for the study of Lesch-Nyhan disease neurological aspects;S Cristini;Hum Mol Genet,2010

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