4-1BB Signaling Activates the T Cell Factor 1 Effector/β-Catenin Pathway with Delayed Kinetics via ERK Signaling and Delayed PI3K/AKT Activation to Promote the Proliferation of CD8+ T Cells

Author:

Lee Do Y.,Choi Beom K.,Lee Don G.,Kim Young H.,Kim Chang H.,Lee Seung J.,Kwon Byoung S.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference41 articles.

1. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death;JC Hurtado;J Immunol,1997

2. In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses;ES Halstead;Nat Immunol,2002

3. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1;HW Lee;J Immunol,2002

4. 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1;HW Lee;Eur J Immunol,2003

5. Immunotherapy of cancer with 4-1BB;DS Vinay;Mol Cancer Ther,2012

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