Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

Author:

Morales-Ramirez Javier,Bogner Johannes R.,Molina Jean-Michel,Lombaard Johan,Dicker Ira B.,Stock David A.,DeGrosky Michelle,Gartland Margaret,Pene Dumitrescu Teodora,Min Sherene,Llamoso Cyril,Joshi Samit R.,Lataillade MaxORCID

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference17 articles.

1. Panel on Antiretroviral Guidelines for Adults and Adolescents, Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available from: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv/0. Cited 1 November 2017.

2. AIDSinfo. FDA-approved HIV medicines. Available from: https://aidsinfo.nih.gov/education-materials/fact-sheets/21/58/fda-approved-hiv-medicines. Cited 1 November 2017.

3. Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease;SC Pettit;J Virol,2002

4. Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites;K Wiegers;J Virol,1998

5. Maturation inhibitors: a new therapeutic class targets the virus structure;K Salzwedel;AIDS Rev,2007

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