Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

Author:

Vickers Timothy A.,Freier Susan M.,Bui Huynh-Hoa,Watt Andrew,Crooke Stanley T.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference42 articles.

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2. Molecular mechanisms of action of antisense drugs;ST Crooke;Biochim, Biophys Acta,1999

3. Crouch RJ, Dirksen M-L (1985) Ribonucleases H. In: Linn SM, Roberts RJ, editors. Nucleases. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. 211–241.

4. Determination of the Role of the Human RNase H1 in the Pharmacology of DNA-like Antisense Drugs;H Wu;Journal of Biological Chemistry,2004

5. Molecular cloning of a ribonuclease H (RNase HI) gene from an extreme thermophile Thermus thermophilus HB8: a thermostable RNase H can functionally replace the Escherichia coli enzyme in vivo;M Itaya;Nucleic Acids Research,1991

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