Abstract
In this paper, a logical-based mathematical model of the cellular pathways involved in the COVID-19 infection has been developed to study various drug treatments (single or in combination), in different illness scenarios, providing insights into their mechanisms of action. Drug simulations suggest that the effects of single drugs are limited, or depending on the scenario counterproductive, whereas better results appear combining different treatments. Specifically, the combination of the anti-inflammatory Baricitinib and the anti-viral Remdesivir showed significant benefits while a stronger efficacy emerged from the triple combination of Baricitinib, Remdesivir, and the corticosteroid Dexamethasone. Together with a sensitivity analysis, we performed an analysis of the mechanisms of the drugs to reveal their impact on molecular pathways.
Publisher
Public Library of Science (PLoS)
Subject
Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics
Reference69 articles.
1. The chronology of the 2002–2003 SARS mini pandemic.;JD Cherry,2004
2. Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus;A Banerjee,2019
3. MERS-coronavirus: From discovery to intervention;W Widagdo;One Heal,2017
4. Epidemiology and pathobiology of SARS-CoV-2 (COVID-19) in comparison with SARS, MERS: An updated overview of current knowledge and future perspectives;B Ganesh;Clin Epidemiol Glob Heal,2021
5. SARS-CoV-2 variants and ending the COVID-19 pandemic;AF Goddard,2021