Systematic review and meta-analysis of Tuberculosis and COVID-19 Co-infection: Prevalence, fatality, and treatment considerations

Author:

Wang QuanORCID,Cao Yanmin,Liu Xinyu,Fu Yaqun,Zhang JiaweiORCID,Zhang Yeqing,Zhang Lanyue,Wei Xiaolin,Yang LiORCID

Abstract

Background Tuberculosis (TB) and COVID-19 co-infection poses a significant global health challenge with increased fatality rates and adverse outcomes. However, the existing evidence on the epidemiology and treatment of TB-COVID co-infection remains limited. Methods This updated systematic review aimed to investigate the prevalence, fatality rates, and treatment outcomes of TB-COVID co-infection. A comprehensive search across six electronic databases spanning November 1, 2019, to January 24, 2023, was conducted. The Joanna Briggs Institute Critical Appraisal Checklist assessed risk of bias of included studies, and meta-analysis estimated co-infection fatality rates and relative risk. Results From 5,095 studies screened, 17 were included. TB-COVID co-infection prevalence was reported in 38 countries or regions, spanning both high and low TB prevalence areas. Prevalence estimates were approximately 0.06% in West Cape Province, South Africa, and 0.02% in California, USA. Treatment approaches for TB-COVID co-infection displayed minimal evolution since 2021. Converging findings from diverse studies underscored increased hospitalization risks, extended recovery periods, and accelerated mortality compared to single COVID-19 cases. The pooled fatality rate among co-infected patients was 7.1% (95%CI: 4.0% ~ 10.8%), slightly lower than previous estimates. In-hospital co-infected patients faced a mean fatality rate of 11.4% (95%CI: 5.6% ~ 18.8%). The pooled relative risk of in-hospital fatality was 0.8 (95% CI, 0.18–3.68) for TB-COVID patients versus single COVID patients. Conclusion TB-COVID co-infection is increasingly prevalent worldwide, with fatality rates gradually declining but remaining higher than COVID-19 alone. This underscores the urgency of continued research to understand and address the challenges posed by TB-COVID co-infection.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Public Library of Science (PLoS)

Reference48 articles.

1. Tuberculosis control: getting back on track in the era of COVID-19;T. Burki;Lancet Respir Med,2022

2. Childhood immunization services accessibility and utilization during the COVID-19 pandemic in Africa;T Dzinamarira;J Infect,2022

3. Global Tuberculosis Report 2020—Reflections on the Global TB burden, treatment and prevention efforts;J Chakaya;Int J Infect Dis,2021

4. The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions;K Dheda;Lancet Respir Med,2022

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