Abstract
Hemorrhagic fever with renal syndrome caused by hantaviruses has long been a serious public health issue in Yunnan Province. Hantaviruses exhibit a high extent of biodiversity in their natural hosts, particularly in mammalian hosts. This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk. Hantaviruses were detected in 202 bats and 372 rodents with the positive rates 27.49% and 1.25% respectively. A novel lineage (named Lineage 10) of the Seoul virus (SEOV) from rodents and the geographic clustering of hantavirus in bats were identified using phylogenetic analyses of the full-length M- and S-segments. Our study suggest a high cross-species transmissibility of hantaviruses in bats and existence of a new lineage of SEOV in rodents differing significantly from other SEOVs. These results provide data to support the prevention and control of hantavirus-associated diseases in Yunnan Province.
Funder
Yunnan Key R&D Program
Yunnan Major Scientific and Technological Projects
Yunnan Province Basic Research Program Projects
National Natural Science Foundation of China
Publisher
Public Library of Science (PLoS)
Reference36 articles.
1. Bunyaviridae genome structure and gene expression;RM Elliott;Curr Top Microbiol Immunol,1991
2. Hantaviruses
3. Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.;WP Guo;PLoS Pathog,2013
4. Hantavirus infections.;T Avšič-Županc;Clin Microbiol Infect,2019
5. A global perspective on hantavirus ecology, epidemiology, and disease.;CB Jonsson;Clin Microbiol Rev,2010