Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients

Author:

Lu Linlin,Zhou Juan,Shi Jian,Peng Xiao-juan,Qi Xiao-xiao,Wang Ying,Li Fang-yuan,Zhou Fu-Yuan,Liu Liang,Liu Zhong-Qiu

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference35 articles.

1. Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications;C Guillemette;Clin Pharmacol Ther,2014

2. Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review;JC Stingl;Pharmacol Ther,2014

3. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus;R Fujiwara;Proc Natl Acad Sci U S A,2010

4. Structural and functional studies of UDP-glucuronosyltransferases;A Radominska-Pandya;Drug Metab Rev,1999

5. Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes;JL Fang;Cancer Res,2002

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