Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method

Author:

Midde Narasimha M.,Rahman Mohammad A.,Rathi Chetan,Li Junhao,Meibohm Bernd,Li Weihua,Kumar Santosh

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference44 articles.

1. HIV integrase inhibitors: a new era in the treatment of HIV;JL Blanco;Expert Opin Pharmacother,2015

2. Integrase inhibitors to treat HIV/AIDS;Y Pommier;Nat Rev Drug Discov,2005

3. Stribild. Elvitegravir/Cobicistat/Emtricitabine/Tenofovir-Clinical Pharmacology Review http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203100Orig1s000ClinPharmR.pdf. [accessed on 2015, July 21}.

4. In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp;DR Mudra;Curr Drug Metab,2011

5. Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors;LL von Moltke;J Clin Pharmacol,2001

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