First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent
Author:
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference17 articles.
1. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects;JE Allen;Science translational medicine,2013
2. Following TRAIL's path in the immune system;C Falschlehner;Immunology,2009
3. Regulation of the human TRAIL gene;JE Allen;Cancer biology & therapy,2012
4. Treating the treatment: toxicity of cancer chemotherapy;IH Plenderleith;Canadian family physician Medecin de famille canadien,1990
5. Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms;S Liu;Cancer treatment reviews,2014
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