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Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

  • Published:2016-01-19 Issue:1 Volume:11 Page:e0147230
  • ISSN:1932-6203
  • Container-title:PLOS ONE
  • language:en
  • Short-container-title:PLoS ONE

Author:

Sullivan Katherine,Cramer-Morales Kimberly,McElroy Daniel L.,Ostrov David A.,Haas Kimberly,Childers Wayne,Hromas Robert,Skorski Tomasz

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference29 articles.

1. DNA repair pathways as targets for cancer therapy;T Helleday;Nat Rev Cancer,2008

2. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase;K Karanam;Mol Cell,2012

3. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells;B Budke;Nucleic Acids Res,2012

4. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death;E Sonoda;EMBO J,1998

5. Double-strand breaks and translocations in cancer;B Elliott;Cell Mol Life Sci,2002

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