Abstract
Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in the activity of putative excitatory and inhibitory neurons—categorized as regular spiking (RS) or fast spiking (FS) according to their action potential (AP) waveform—comparing before and after learning of a whisker detection task with delayed licking as perceptual report. Surprisingly, we found that the whisker-evoked activity of RS versus FS neurons changed in opposite directions after learning in primary and secondary whisker motor cortices, while it changed similarly in primary and secondary orofacial motor cortices. Our results suggest that changes in the balance of excitation and inhibition in local circuits concurrent with changes in the long-range synaptic inputs in distinct cortical regions might contribute to performance of delayed sensory-to-motor transformation.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
European Research Council
H2020 Marie Skłodowska-Curie Actions
Research Foundation for Opto-science and Technology
Brain Science Foundation
Japan Society for the Promotion of Sciences
Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
Publisher
Public Library of Science (PLoS)
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Cited by
4 articles.
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