Abstract
Trichoplax adhaerens is the simplest multicellular animal with tissue differentiation and somatic cell turnover. Like all other multicellular organisms, it should be vulnerable to cancer, yet there have been no reports of cancer in T. adhaerens or any other placozoan. We investigated the cancer resistance of T. adhaerens, discovering that they are able to tolerate high levels of radiation damage (218.6 Gy). To investigate how T. adhaerens survive levels of radiation that are lethal to other animals, we examined gene expression after the X-ray exposure, finding overexpression of genes involved in DNA repair and apoptosis including the MDM2 gene. We also discovered that T. adhaerens extrudes clusters of inviable cells after X-ray exposure. T. adhaerens is a valuable model organism for studying the molecular, genetic, and tissue-level mechanisms underlying cancer suppression.
Funder
NIH
National Institutes of Health
CDMRP Breast Cancer Research Program
Arizona Biomedical Research Commission
Publisher
Public Library of Science (PLoS)
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Reference65 articles.
1. Cancer across the tree of life: cooperation and cheating in multicellularity;CA Aktipis;Philos Trans R Soc Lond B Biol Sci,2015
2. Peto’s Paradox: how has evolution solved the problem of cancer prevention?;M Tollis;BMC Biol,2017
3. Peto’s paradox and the promise of comparative oncology;L Nunney;Philos Trans R Soc Lond B Biol Sci,2015
4. Peto’s Paradox: evolution’s prescription for cancer prevention;AF Caulin;Trends Ecol Evol,2011
5. Cancer and Aging in Mice and Men;R Peto;Br J Cancer,1975
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