Applying an evolutionary mismatch framework to understand disease susceptibility
-
Published:2023-09-11
Issue:9
Volume:21
Page:e3002311
-
ISSN:1545-7885
-
Container-title:PLOS Biology
-
language:en
-
Short-container-title:PLoS Biol
Author:
Lea Amanda J.ORCID,
Clark Andrew G.,
Dahl Andrew W.,
Devinsky Orrin,
Garcia Angela R.,
Golden Christopher D.,
Kamau Joseph,
Kraft Thomas S.,
Lim Yvonne A. L.,
Martins Dino J.,
Mogoi Donald,
Pajukanta Päivi,
Perry George H.,
Pontzer Herman,
Trumble Benjamin C.,
Urlacher Samuel S.,
Venkataraman Vivek V.,
Wallace Ian J.,
Gurven Michael,
Lieberman Daniel E.,
Ayroles Julien F.ORCID
Abstract
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare throughout human history but are now common. The evolutionary mismatch hypothesis posits that humans evolved in environments that radically differ from those we currently experience; consequently, traits that were once advantageous may now be “mismatched” and disease causing. At the genetic level, this hypothesis predicts that loci with a history of selection will exhibit “genotype by environment” (GxE) interactions, with different health effects in “ancestral” versus “modern” environments. To identify such loci, we advocate for combining genomic tools in partnership with subsistence-level groups experiencing rapid lifestyle change. In these populations, comparisons of individuals falling on opposite extremes of the “matched” to “mismatched” spectrum are uniquely possible. More broadly, the work we propose will inform our understanding of environmental and genetic risk factors for NCDs across diverse ancestries and cultures.
Funder
Canadian Institute for Advanced Research
Searle Scholars Program
National Institute of General Medical Sciences
National Institute of Environmental Health Sciences
Publisher
Public Library of Science (PLoS)
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献