Differences in the functional brain architecture of sustained attention and working memory in youth and adults

Author:

Kardan OmidORCID,Stier Andrew J.,Cardenas-Iniguez Carlos,Schertz Kathryn E.,Pruin Julia C.,Deng Yuting,Chamberlain Taylor,Meredith Wesley J.,Zhang Xihan,Bowman Jillian E.,Lakhtakia Tanvi,Tindel Lucy,Avery Emily W.,Lin Qi,Yoo Kwangsun,Chun Marvin M.,Berman Marc G.,Rosenberg Monica D.

Abstract

Sustained attention (SA) and working memory (WM) are critical processes, but the brain networks supporting these abilities in development are unknown. We characterized the functional brain architecture of SA and WM in 9- to 11-year-old children and adults. First, we found that adult network predictors of SA generalized to predict individual differences and fluctuations in SA in youth. A WM model predicted WM performance both across and within children—and captured individual differences in later recognition memory—but underperformed in youth relative to adults. We next characterized functional connections differentially related to SA and WM in youth compared to adults. Results revealed 2 network configurations: a dominant architecture predicting performance in both age groups and a secondary architecture, more prominent for WM than SA, predicting performance in each age group differently. Thus, functional connectivity (FC) predicts SA and WM in youth, with networks predicting WM performance differing more between youths and adults than those predicting SA.

Funder

National Institute on Alcohol Abuse and Alcoholism

National Science Foundation

National Institute of Mental Health

University of Chicago

Publisher

Public Library of Science (PLoS)

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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