Abstract
Although less common than the evolution of antimicrobial drug resistance, vaccine resistance can and has evolved. How likely is it that COVID-19 vaccines currently in development will be undermined by viral evolution? We argue that this can be determined by repurposing samples that are already being collected as part of clinical trials. Such information would be useful for prioritizing investment among candidate vaccines and maximizing the potential long-term impact of COVID-19 vaccines.
Publisher
Public Library of Science (PLoS)
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Reference14 articles.
1. World Health Organization. Draft landscape of COVID-19 candidate vaccines. 19 October 2020. [cited 2020 Oct 23]. Available from: https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines.
2. Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance;DA Kennedy;Proc Natl Acad Sci USA,2018
3. Vaccination against colonizing bacteria with multiple serotypes;M. Lipsitch;Proc Natl Acad Sci USA,1997
4. Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection;S Octavia;Mol Biol Evol,2011
5. Imperfect vaccination can enhance the transmission of highly virulent pathogens;AF Read;PLoS Biol,2015
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