Abstract
Aims
This systematic review aimed to study the hippocampal and frontal changes of heart failure (HF) patients and HF animal models with cognitive impairment or depression.
Methods
A systematic review of the literature was conducted independently by reviewers using PubMed, Web of Science, Embase, and the Cochrane Library databases.
Results and conclusions
30 studies were included, involving 17 pieces of clinical research on HF patients and 13 studies of HF animal models. In HF patients, the hippocampal injuries were shown in the reduction of volume, CBF, glucose metabolism, and gray matter, which were mainly observed in the right hippocampus. The frontal damages were only in reduced gray matter and have no difference between the right and left sides. The included HF animal model studies were generalized and demonstrated the changes in inflammation and apoptosis, synaptic reduction, and neurotransmitter disorders in the hippocampus and frontal lobes. The results of HF animal model studies complemented the clinical observations by providing potential mechanistic explanations of the changes in the hippocampus and frontal lobes.
Funder
National Natural Science Foundation of China
Publisher
Public Library of Science (PLoS)
Reference66 articles.
1. Epidemiology and aetiology of heart failure;B Ziaeian;Nat Rev Cardiol,2016
2. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes;T Rutledge;J Am Coll Cardiol,2006
3. Cognitive Impairment and Heart Failure: Systematic Review and Meta-Analysis;JA Cannon;J Card Fail,2017
4. Depression and heart failure: the lonely comorbidity;M Sbolli;Eur J Heart Fail,2020
5. Heart failure and cognitive dysfunction;J Ampadu;Int J Cardiol,2015
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