Abstract
Objective
Coronary artery disease (CAD) is a leading cause of death worldwide. Many studies in China and abroad have reported an association between the expression level of microRNA-155 and CAD; however, the results remain controversial. We aimed to comprehensively investigate this association based on a meta-analysis.
Methods
We first systematically searched eight Chinese and English databases, including China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, PubMed, Web of Science, Embase, Google Scholar, and Cochrane Library, to identify studies concerning the relationship between microRNA-155 levels and CAD published before February 7, 2021. The quality of the literature was assessed by the Newcastle–Ottawa Scale (NOS). Meta-analysis was performed using a random-effects model to calculate the standard mean difference with a 95% confidence interval (CI).
Results
Sixteen articles with a total of 2069 patients with CAD and 1338 controls were included. All the articles were of high quality according to the NOS. The meta-analysis showed that the mean level of microRNA-155 was significantly lower in patients with CAD than in controls. Based on subgroup analyses, the level of microRNA-155 in the plasma of CAD patients and in acute myocardial infarction (AMI) patients was significantly lower than that in controls, whereas this level in CAD patients with mild stenosis was significantly higher than that in controls.
Conclusion
Our study indicates that the expression level of circulating microRNA-155 in patients with CAD is lower than that in a non-CAD group, suggesting a new possible reference index for the diagnosis and monitoring of patients with CAD.
Funder
Natural Science Foundation of Chongqing
the Joint Medical Research Project of Chongqing Municipal Science and Health Commission
Publisher
Public Library of Science (PLoS)
Reference31 articles.
1. MicroRNAs and cardiovascular diseases.;T Nishiguchi;BioMed research international.,2015
2. Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease;J Faccini;Scientific reports,2017
3. Correlation between CD4~+t lymphocyte microRNA 155 level and coronary artery disease in patients with unstable angina pectoris;Q Su;Journal of clinical cardiovascular disease,2014
4. The relationships among monocyte subsets, miRNAs and inflammatory cytokines in patients with acute myocardial infarction.;E Kazimierczyk;Pharmacological reports: PR.Epub 2018,2019
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