High prevalence of sexual infection by human papillomavirus and Chlamydia trachomatis in sexually-active women from a large city in the Amazon region of Brazil

Author:

dos Santos Leonardo MirandaORCID,de Souza Josiellem DamascenoORCID,Mbakwa Hilary Acha,Nobre Akim Felipe Santos,Vieira Rodrigo Covre,Ferrari Stephen Francis,Rodrigues Anderson Raiol,Ishikawa Edna Aoba Yassui,Guerreiro João Farias,de Sousa Maísa Silva

Abstract

Background The Human Papillomavirus (HPV) and Chlamydia trachomatis are the most prevalent Sexually Transmitted Infections (STIs) worldwide, and are associated cervical cancer and pelvic inflammatory disease, respectively. However, 80% of women testing positive are asymptomatic. In the Amazon region, young women, in particular, are widely exposed to the infections and their consequences. Objectives Determine the prevalence of sexual infection by HPV and C. trachomatis in young, sexually-active women treated at a university health program in a large city of the Brazilian Amazon region. Methods We amplified the L1 gene of HPV. We amplified ompA gene of C. trachomatis by nested PCR, and the study participants filled in a questionnaire on their social, epidemiological, and reproductive health characteristics. The data were analyzed using the Odds Ratio, to evaluate the degree of association of these variables with the observed infections. Results The prevalence of infection by HPV was 15.5% (47/303). This infection was recorded in 32.2% of the women of less than 25 years of age (OR:3.02 [CI95%] = 1.32–6.92; p = 0.014), 17.9% of the single women (OR: 2.41 [CI95%] = 1.22–4.75; p = 0.014), 23.8% of the women that reported having first sexual intercourse at less than 15 years of age (OR: 2.22 [CI95%] = 1.16–4.23; p = 0.021), 20% of those that reported having had more than one sexual partner during their lifetime (OR: 3.83 [CI95%] = 1.56–9.37; p = 0.003), and in 28.3% that use oral contraceptives (CI95% = 1.33–5.43; p = 0.008). The prevalence of sexual infection by C. trachomatis was 4.6% (14/303), and this bacterium was present in 16.1% of the young women of less than 25 years of age (OR: 2.86 [CI95%] = 1.33–5.43; p = 0.008). Conclusions We found a high prevalence of HPV in young, unmarried women who started their sex lives early, who had several sexual partners in their lives and who used oral contraceptives. The prevalence of C. trachomatis was high only in young women. Our data are in accordance with other studies in Brazil and in the world and may serve to base the formulation of diagnostic and screening measures for these infections in women in the Amazon.

Funder

Pará State Amazonian Research Foundation

Brazilian Ministry of Health

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference46 articles.

1. HPV 6-associated HSIL/Squamous Carcinoma in the Anogenital Tract;MZ Liu;Int J Gynecol Pathol,2019

2. Cervical Cancer;PA Cohen;Lancet,2019

3. Relation Between Chlamydia trachomatis Infection and Pelvic Inflammatory Disease, Ectopic Pregnancy and Tubal Factor Infertility in a Dutch Cohort of Women Previously Tested for Chlamydia in a Chlamydia Screening Trial;BM Hoenderboom;Sex Transm Infect,2019

4. Chlamydia Trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients;CDJ Heijer;Clin Infect Dis,2019

5. Human Papillomavirus Molecular Biology;ME Harden;Review. Mutat Res Rev Mutat Res.,2017

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3